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Laurel Hind is studying the signals that regulate the immune system and contribute to disease, supported by a major grant awarded to promising early-career faculty.

Hind, an assistant professor in the Department of Chemical and Biological Engineering at the ��«����Ƶ, has received a prestigious National Science Foundation CAREER Award. This highly competitive program supports faculty with potential to become leaders in research and education.

The $646,000, five-year grant will support Hind's research on how the tissue environment directs the innate immune response. It will also fund outreach efforts to improve scientific literacy in immunology through a new program, “Immunology in our Everyday Lives."

“I am grateful for this award because it recognizes and builds on the work my students have done to understand how the tissue environment regulates innate immunity while also opening a completely new research area for my lab, which is very exciting," Hind said. "I am happy that the field recognizes the importance of understanding how physical cues regulate cell function.”

The innate immune response acts as the body's first line of defense against harmful invaders like bacteria or viruses, injuries and disease, and plays a critical role in maintaining health. However, an imbalance in the immune system can lead to inappropriate responses which are increasingly linked to diseases such as cancer, cardiovascular disease, chronic infections and fibrosis, and aging, Hind said. Understanding the signals that control this response and how they become dysregulated in disease could help develop new treatments.��

The award will support Hind and her team in exploring how physical changes in tissues affect immune function and contribute to worsened disease outcomes as diseases affected by immune system problems often involve changes in the physical properties of tissues. For example, tissues become stiffer in cancer and fibrotic diseases, but lose structure during the aging process. While the chemical signals that influence the immune system in these processes are well studied, how the physical properties of tissues impact immunity is not yet fully understood.

Using novel biomaterials in an innovative “inflammation-on-a-chip” device, Hind and her team will examine how properties such as stiffness, elasticity and the dynamics of tissue stiffening affect innate immune cell function. Importantly, it will identify the genes and proteins that drive these changes, providing targets for future therapeutic development.

The award will also support the development of a curriculum to improve scientific literacy in immunology to encourage public health initiatives through community-engaged outreach. This curriculum will use games and hands-on activities to explain how antibiotics and antibodies work and demonstrate the importance of herd immunity. It will also help retain and recruit women and historically excluded students in science and engineering by involving them in research and curriculum development.

“Public health initiatives like broad participation in vaccination and reducing the overuse of antibiotics are so important for the health of our communities, yet many people don’t understand why, which can lead to resistance," Hind said. "I am excited to share our knowledge in an accessible way with students and families in our community.”