Robert Sievers

  • Professor Emeritus
  • CHEMISTRY
Address

Office: Ekeley W281

Education

Ph.D.: University of Illinois, 1960

Areas of Expertise

Environmental Chemistry, Instrument Development, Bioanalytical Chemistry, Aerosols & Clouds

Awards and Honors

  • 2009 Governors Award for Research Impact
  • 2008 ACS Astellas Award
  • 2004 Pinnacle of Inventorship Award, University of Colorado
  • 2003 Robert L. Stearns Faculty Award, University of Colorado Alumni Association
  • 2001 Thomas Jefferson Award, University of Colorado
  • 1992: Keene P. Dimick Award in Chromatography, Pittsburgh Conf. on Analytical Chemistry.
  • 1985: Gold Medal Award, Colorado Section, American Chemical Society.
  • 1981: Tswett Chromatography Medal, Barcelona, Spain.

" Successful Respiratory Immunization With Dry Powder Live-Attenuated Measles Virus Vaccine In Rhesus Macaques,” W-H. Lin, D.E. Griffin, P.A. Rota, M.J. Papania, S.P. Cape, D.J.Bennett, B.P.Quinn, R.E. Sievers, C.D. Shermer, K.G. Powell, R.J. Adams, C.S. Godin and S.E.Winston, Proceedings of the National Academy of Sciences, 2011; DOI:10.1073/pnas.1017334108.

"Dry Powder Measles Vaccine: Particle Deposition, Virus Replication, And Immune Response in Cotton Rats Following Inhalation,” K.O. Kisich, M.P. Higgins, I. Park, S.P. Cape, L. Lindsay, D.J. Bennett, S. Winston, J. Searles, R.E. Sievers, Vaccine, 29, 905-911, 2011.

"Processing of Oligonucleotides into Picroparticles Suitable for Inhalation," P. Pathak, B.P. Quinn, L.G. Rebits, R.E. Sievers, Journal of Medicine and Pulmonary Drug Delivery, 22:2, 186, 2009.

"An Inhalation Safety Study of Myo-inositol, A Non-Hygroscopic Stabilizing Excipient in Dispersible Microparticles, D.H. McAdams, S.P. Cape, W.E. Winston, S. Godin, K.G. Powell, C.D. Shermer, L. Chan, P. Pathak, R.E. Sievers, Journal of Medicine and Pulmonary Drug Delivery, 22:2, 199, 2009.

"Are Unit-dose Dry Powder Vaccines Intrinsically Safer than Liquid Vaccines, R.E. Sievers, E.L. Sievers, J.A. Searles, S.P. Cape, D.H. McAdams, J.L. Burger, J.R. Manion, D. Griffin, W-H Lin, P. Rota, M. Papania, S. Winston, B.P. Quinn, D.M. Krank, P. Pathak, P.A. Bhagwat, L.G. Rebits, S. Evans, J. Pharmacy and Pharmacology, Supplement 1 A163-164, September 2009.

"Nanomedicine for Respiratory Diseases," H. Swai, B. Semete, L. Kalombo, P. Chelule, K. Kisich, R. Sievers, Nanomed Nanobiotechnol 1, 255-263, 2009.

“Challenges of Developing a Stable Dry Powder Live Viral Vaccine,” R.E. Sievers, S.P. Cape, K.O. Kisich, D.J. Bennett, C.S. Braun, J.L. Burger, J.A. Best, D.H. McAdams, N.A. Wolters, B.P. Quinn, J.A. Searles, D.M. Krank, P. Pathak, P.A. Bhagwat, L.G. Rebits, RDD 2008, Vol. 1, 281-290, 2008.

“The PuffHaler®: a Simple Active DPI with a Pressure Release Valve Dispenser,” D.J. Bennett, R.E. Sievers, S.P. Cape, J.A. Best, A.L. Morin, C.A. Pelzmann, B.P. Quinn, L.G. Rebits, S. Evans, R.D. Threadgill, D.H. McAdams, RDD 2008, Vol. 2, 345-350, 2008.

“CAN-BD Processing of Active and Respirable siRNA particles for Pulmonary Delivery,” P. Pathak, B.P. Quinn, L.G. Rebits, R.E. Sievers, RDD 2008, Vol. 2, 351-354, 2008.

“Stabilizing Formulations for Inhalable Powders of Live-Attenuated Measles Virus Vaccine,” J.L. Burger, S.P. Cape, C.S. Braun, D.H. McAdams, J.A. Best, P. Bhagwat, P. Pathak, L.G. Rebits, R.E. Sievers, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 21:1, 25-34 (March 2008).

“Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-critical Fluids,” S.P. Cape, J.A. Villa, E.T. Huang, T.-H. Yang, J.F. Carpenter, and R.E. Sievers, Pharmaceutical Research 25 (9), 1967-1990 (2008).

Stabilization of Measles Virus for Vaccine Formulation,” J. Kissmann, S.F. Ausar, A. Randolph, C. Braun, S.P. Cape, R.E. Sievers, M.J. Federspiel, and C.R. Middaugh, Human Vaccines, 4(5), 350-359 (2008).

“Method for Quantifying the Sample Collected by an Andersen Cascade Impactor Using Total Organic Carbon Analysis,” L.G. Rebits, D.J. Bennett, P.A. Bhagwat, A. Morin, R.E. Sievers, Journal of Aerosol Science 38 (12), 1197-1206 (2008).

“Near Critical Fluid Micronization of Stabilized Vaccines, Antibiotics and Anti-virals,” R.E. Sievers, B.P. Quinn, S.P. Cape, J.A. Searles, C.S. Braun, P. Bhagwat, L.G. Rebits, D.H. McAdams, J.L. Burger, J.A. Best, L. Lindsay, M.T. Hernandez, K.O. Kisich, T. Iacovangelo, D. Kristensen, D. Chen, J. Supercritical Fluids 42 (3), Sp. Iss. SI, 385-391 (Oct. 2007).

“Stabilization, Nebulization, and Near-ambient Temperature Drying of Measles Vaccine, IgG Antibody, TB Antibiotics, and Zanamivir,” R.E. Sievers, S.P. Cape, B.P. Quinn, J.A. Searles, J.A. Best, J.L. Burger, D.H. McAdams, and L.G. Rebits. Proceedings of the Respiratory Drug Delivery X, April 23 - 27, Boca Raton, FL (USA), pp. 409-412 (2006).

“Supercritical Fluid-assisted Nebulization and Bubble Drying,” R.E. Sievers, S.P. Sellers, and J.F. Carpenter, Australian Patent 782916, Sept. 8, 2005.

“Synthesis of Composite Microparticles with a Mixing Cross, J.A. Villa, E.T.S. Huang, S.P. Cape, and R.E. Sievers, Aerosol Science and Technology, 39(6), 473-484 (2005).

“Fine Particle Pharmaceutical Manufacturing Using Dense Carbon Dioxide Mixed with Aqueous or Alcoholic Solutions,” E.T.S. Huang, H-Y Chang, C.D. Liang, and R.E. Sievers, ACS Symp. Ser. 860, 324-338 (2003).

“Micronization of Inhalable Drugs with Liquid Carbon Dioxide at Near Ambient Conditions,” R. Sievers, G. Clark, J. Villa, D. Alargov, L. Rinner, S. Cape, and E. Huang, Journal of Aerosol Medicine, 16, 213 (2003).

“Micronization of Water-Soluble or Alcohol-Soluble Pharmaceuticals with a Low Temperature Bubble Dryer®,” R.E. Sievers, E.T.S. Huang, J.A. Villa, G. Engling, Journal of Supercritical Fluids, 26, 9-16 (2003).