/lab/aaron-whiteley/ en /lab/aaron-whiteley/2024/02/28/conservation-and-similarity-bacterial-and-eukaryotic-innate-immunity <span>Review: Conservation and similarity of bacterial and eukaryotic innate immunity</span> <span><span>Anonymous (not verified)</span></span> <span><time datetime="2024-02-28T14:45:59-07:00" title="Wednesday, February 28, 2024 - 14:45">Wed, 02/28/2024 - 14:45</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/lab/aaron-whiteley/sites/default/files/styles/focal_image_wide/public/article-thumbnail/screenshot_2024-02-28_at_2.44.58_pm_0.png?h=80a4075b&amp;itok=rnJUzTUb" width="1200" height="800" alt="Conservation and similarity of immunity"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/lab/aaron-whiteley/taxonomy/term/348"> Reviews </a> <a href="/lab/aaron-whiteley/taxonomy/term/153"> Spotlight Publications </a> </div> <a href="/lab/aaron-whiteley/hannah-ledvina">Hannah Ledvina</a> <span>,&nbsp;</span> <a href="/lab/aaron-whiteley/aaron-whiteley">Aaron Whiteley</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><p><em>Nat Rev Microbiol (</em>2024).&nbsp;<span>PubMed PMID: 38418927; PubMed Central PMCID: </span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389603/" rel="nofollow"><span>PMC11389603</span></a><span>.</span></p><h2>Abstract</h2><p>Pathogens are ubiquitous and a constant threat to their hosts, which has led to the evolution of sophisticated immune systems in bacteria, archaea and eukaryotes. Bacterial immune systems encode an astoundingly large array of antiviral (antiphage) systems, and recent investigations have identified unexpected similarities between the immune systems of bacteria and animals. In this Review, we discuss advances in our understanding of the bacterial innate immune system and highlight the components, strategies and pathogen restriction mechanisms conserved between bacteria and eukaryotes. We summarize evidence for the hypothesis that components of the human immune system originated in bacteria, where they first evolved to defend against phages. Further, we discuss shared mechanisms that pathogens use to overcome host immune pathways and unexpected similarities between bacterial immune systems and interbacterial antagonism. Understanding the shared evolutionary path of immune components across domains of life and the successful strategies that organisms have arrived at to restrict their pathogens will enable future development of therapeutics that activate the human immune system for the precise treatment of disease.</p><h2>News and Commentaries</h2><ul><li><a href="https://x.com/HannahLedvina/status/1763664742311231679" rel="nofollow">Read Hannah's Tweetorial </a>[Twitter]</li></ul><h2>Links</h2><ul><li>DOI:&nbsp;<a href="https://doi.org/10.1038/s41579-024-01017-1" rel="nofollow">https://doi.org/10.1038/s41579-024-01017-1</a></li><li>Sharable Link:&nbsp;<a href="https://rdcu.be/dzSa3" rel="nofollow">https://rdcu.be/dzSa3</a></li><li>Journal Link: <a href="https://www.nature.com/articles/s41579-024-01017-1" rel="nofollow">https://www.nature.com/articles/s41579-024-01017-1</a></li></ul><h2>Citation</h2><p><span>Ledvina HE, Whiteley AT. </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/38418927/" rel="nofollow">Conservation and similarity of bacterial and eukaryotic innate immunity. </a><span>Nat Rev Microbiol. 2024 Jul;22(7):420-434. doi: 10.1038/s41579-024-01017-1. Epub 2024 Feb 28. Review. PubMed PMID: 38418927; PubMed Central PMCID: PMC11389603.</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default"> <div> <div class="imageMediaStyle large_image_style"> <img loading="lazy" src="/lab/aaron-whiteley/sites/default/files/styles/large_image_style/public/article-image/screenshot_2024-02-28_at_2.44.58_pm.png?itok=8AMQePTc" width="1500" height="1577" alt="Conservation and similarity of immunity"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div>Ledvina, HE, ➤Whiteley, AT | Nature Reviews Microbiology 2024</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Wed, 28 Feb 2024 21:45:59 +0000 Anonymous 186 at /lab/aaron-whiteley