/lab/aaron-whiteley/ en /lab/aaron-whiteley/2024/12/05/commentary-phages-gain-upper-hand-metabolic-arms-race-nad <span>Commentary: Phages gain the upper hand in the metabolic arms race for NAD+</span> <span><span>Aaron Whiteley</span></span> <span><time datetime="2024-12-05T09:00:00-07:00" title="Thursday, December 5, 2024 - 09:00">Thu, 12/05/2024 - 09:00</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/lab/aaron-whiteley/sites/default/files/styles/focal_image_wide/public/2024-12/Bullen%20at%20al%202024%20Thumbnail_0.png?h=bc4646fb&amp;itok=HElVk44T" width="1200" height="800" alt="Bullen at al 2024 Thumbnail"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/lab/aaron-whiteley/taxonomy/term/350"> Commentaries </a> </div> <a href="/lab/aaron-whiteley/nathan-bullen">Nathan Bullen</a> <span>,&nbsp;</span> <a href="/lab/aaron-whiteley/aaron-whiteley">Aaron Whiteley</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><p><em><span>Molecular Cell</span></em><span> (2024). PubMed PMID: </span><a href="https://pubmed.ncbi.nlm.nih.gov/39642854/" rel="nofollow"><span>39642854</span></a><span>.</span></p><h2>Abstract</h2><p><span>Bacteria often defend against phage infection by deploying NADase effectors to degrade cellular NAD</span>⁺<span>, thereby halting both bacterial growth and phage replication. In a recent article in Nature, Osterman et al.</span>¹<span> identify phage-encoded counterdefense pathways that reconstitute NAD</span>⁺<span> during infection, enabling phages to combat multiple unrelated antiphage systems.</span></p><h2>Links</h2><ul><li>DOI:&nbsp;<a href="https://doi.org/10.1016/j.molcel.2024.11.017" rel="nofollow">https://doi.org/10.1038/s41579-024-01017-1</a></li><li>Journal Link:&nbsp;<a href="https://www.sciencedirect.com/science/article/pii/S1097276524009225" rel="nofollow">https://www.sciencedirect.com/science/article/pii/S1097276524009225</a></li></ul><h2>Citation</h2><p><span>Bullen NP, Whiteley AT. </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/39642854/" rel="nofollow">Phages gain the upper hand in the metabolic arms race for NAD(). </a><span>Mol Cell. 2024 Dec 5;84(23):4480-4482. doi: 10.1016/j.molcel.2024.11.017. PubMed PMID: 39642854.</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default"> <div> <div class="imageMediaStyle large_image_style"> <img loading="lazy" src="/lab/aaron-whiteley/sites/default/files/styles/large_image_style/public/2024-12/Bullen%20at%20al%202024%20Thumbnail_0.png?itok=xur8c3H3" width="1500" height="1500" alt="Bullen at al 2024 Thumbnail"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div>Bullen NP, ➤Whiteley AT | Molecular Cell 2024</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Thu, 05 Dec 2024 16:00:00 +0000 Aaron Whiteley 195 at /lab/aaron-whiteley /lab/aaron-whiteley/2020/11/19/linguistics-bacterial-conflict-systems-reveal-ancient-origins-eukaryotic-innate-immunity <span>Commentary: The linguistics of bacterial conflict systems reveal ancient origins of eukaryotic innate immunity</span> <span><span>Anonymous (not verified)</span></span> <span><time datetime="2020-11-19T08:00:00-07:00" title="Thursday, November 19, 2020 - 08:00">Thu, 11/19/2020 - 08:00</time> </span> <div> <div class="imageMediaStyle focal_image_wide"> <img loading="lazy" src="/lab/aaron-whiteley/sites/default/files/styles/focal_image_wide/public/article-thumbnail/screen_shot_2020-12-11_at_1.39.19_pm.png?h=345cd43a&amp;itok=DGzZvpyX" width="1200" height="800" alt="JB Commentary"> </div> </div> <div role="contentinfo" class="container ucb-article-categories" itemprop="about"> <span class="visually-hidden">Categories:</span> <div class="ucb-article-category-icon" aria-hidden="true"> <i class="fa-solid fa-folder-open"></i> </div> <a href="/lab/aaron-whiteley/taxonomy/term/350"> Commentaries </a> </div> <div role="contentinfo" class="container ucb-article-tags" itemprop="keywords"> <span class="visually-hidden">Tags:</span> <div class="ucb-article-tag-icon" aria-hidden="true"> <i class="fa-solid fa-tags"></i> </div> <a href="/lab/aaron-whiteley/taxonomy/term/215" hreflang="en">CBASS antiphage immunity</a> <a href="/lab/aaron-whiteley/taxonomy/term/159" hreflang="en">STING</a> <a href="/lab/aaron-whiteley/taxonomy/term/149" hreflang="en">bacteriophage immunity</a> </div> <a href="/lab/aaron-whiteley/emily-kibby">Emily Kibby</a> <span>,&nbsp;</span> <a href="/lab/aaron-whiteley/aaron-whiteley">Aaron Whiteley</a> <div class="ucb-article-content ucb-striped-content"> <div class="container"> <div class="paragraph paragraph--type--article-content paragraph--view-mode--default 3"> <div class="ucb-article-row-subrow row"> <div class="ucb-article-text col-lg d-flex align-items-center" itemprop="articleBody"> <div><p><em>Journal of Bacteriology</em> (2020) <span>PubMed PMID: 32958633; PubMed Central PMCID: </span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685558/" rel="nofollow"><span>PMC7685558</span></a><span>.</span></p><h2>Abstract</h2><p>The arms-race between bacteria and their competitors has produced an astounding variety of conflict systems that are shared via horizontal gene transfer across bacterial populations. In this issue of&nbsp;<em>Journal of Bacteriology</em>, Burroughs and Aravind investigate how these biological conflict systems have been mixed-and-matched into new configurations, often with novel protein domains. The authors additionally characterize the evolutionary history of genes in eukaryotes that appear to have been acquired from these prokaryotic defense systems.</p><h2>Links&nbsp;</h2><ul><li>DOI:&nbsp;<a href="https://doi.org/10.1128/jb.00507-20" rel="nofollow">10.1128/JB.00507-20</a></li><li>Journal Link: <a href="https://journals.asm.org/doi/10.1128/jb.00507-20" rel="nofollow">https://journals.asm.org/doi/10.1128/jb.00507-20</a></li></ul><h2>Citation</h2><p><span>Kibby EM, Whiteley AT. </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/32958633/" rel="nofollow">The Linguistics of Bacterial Conflict Systems Reveal Ancient Origins of Eukaryotic Innate Immunity. </a><span>J Bacteriol. 2020 Nov 19;202(24). doi: 10.1128/JB.00507-20. Print 2020 Nov 19. PubMed PMID: 32958633; PubMed Central PMCID: PMC7685558.</span></p></div> </div> <div class="ucb-article-content-media ucb-article-content-media-right col-lg"> <div> <div class="paragraph paragraph--type--media paragraph--view-mode--default"> </div> </div> </div> </div> </div> </div> </div> <div>Kibby EM, ➤Whiteley AT. | J. Bacteriology 2020</div> <h2> <div class="paragraph paragraph--type--ucb-related-articles-block paragraph--view-mode--default"> <div>Off</div> </div> </h2> <div>Traditional</div> <div>0</div> <div>On</div> <div>White</div> Thu, 19 Nov 2020 15:00:00 +0000 Anonymous 125 at /lab/aaron-whiteley