Impact Report
Drug resistance is arguably one of the most significant medical challenges of our era, costingmillions of lives a year. Antibiotics, once a miracle cure against deadly bacterial infections, have bred antibiotic-resistant bugs that now defy all treatments. Meanwhile, cancers continue to evade even our most advanced treatments and a cure remains elusive. Despite our greatest efforts, these challenges remain beyond the reach of the medical research.Rising to the challenge, BioFrontiers has assembled a dream team of researchers to face off against modern medicine’s greatest foe.
The human papillomavirus (HPV) vaccine was a landmark first in cancer prevention, protecting women against the virus that causes cervical cancers. Yet this life-saving vaccine and many others remain inaccessible to a large part of the developing world due to their high cost and need for refrigeration. Many have tried to overcome these barriers to universal vaccination, but thus far, all have fallen short.Now BioFrontiers scientist Bob Garcea and collaborator, Ted Randolph, promise to finally break down these barriers with a fresh, cross-disciplinary approach.
Despite the widespread popularity of “interdisciplinarity” (a major buzz-word in current bioscience research), few programs deliver on its promise. BioFrontiers’ Interdisciplinary Quantative Biology PhD Certificate Program (IQ Biology) is a rare breed, designed from the ground up to break down academic silos, and foster cross-disciplinary collaboration. This unique program trains the next generation of innovation leaders, laying the foundation for tomorrow’s bioscience advances.To secure the future of the program, BioFrontiers advisory board members Chris Christoffersen, Ken Hitchner, Jim Linfield, and Jeannie Thompson, along with their families, joined together to fund the Cech-Leinwand Endowed Graduate Fellowship.
Joey Azofeifacame to CU «Ƶ looking for a challenge. While he applied to many top notch biology programs, the IQ Biology Program spoke to him as the only place he couldchallenge himself and gain new perspective by delving into a completely new field—computational biology. “IQ Biology brings people in from diverse backgrounds and investsin them. They reallytook a chance on me and bridged across departments to train me and get me where I wanted to go,” says Joey. The chance paid off, as Joey threw himself into computational studies and interdisciplinary research thatbridged genomics and machine learninginways that had never been done before.
As part of a focused effort to expand the BioFrontiers Institute’s research portfolio in Computational Biology, five new faculty were recently recruited. Dan Larremore and John Rinn came on board in Fall 2017, andOrit Peleg arrived in Spring 2018.Ed Chuong and Ryan Layer will arrive in Fall 2018 (Stay tuned!). With advances in technology that are providing researchers with vast quantities of biologicaldata to manage andinterpret, their expertise and ability to converse in more than one scientific discipline will help identify usefulinformation in large sets of unsorted, disorderly data.
Innovative faculty make their mark. As recognition of their pioneering advances inbiotechnology, the National Academy ofInventors (NAI) has welcomed five BioFrontiers faculty to its ranks in the last three years. Marvin Caruthers and Larry Gold now join their colleagues Leslie Leinwand (2016), Christopher Bowman(2016), and Kristi Anseth (2015) in this exclusive club. These distinguished faculty are recognized not onlyfor their leadership in forging new frontiers in biosciences, but also for their noteworthy impactson quality of life, economic development andwelfare of society.
As «Ƶ’s biotech community continues to thrive and grow, The Jennie Smoly Caruthers Biotechnology Building debuted its state-of-the-art E-Wing in August of 2017. The 56,340-square-foot E-Wing features next-generation spaces where students and faculty cancontinue their groundbreaking interdisciplinary research.
BioFrontiers faculty exhibit a wealth of competence and innovation in their research. In recognition of their hard work, our faculty have received a variety of rewards.
Integrating Research Across Campus
Our community ofcross-disciplinary scientists and engineers in10 affiliated departmentsare empowered to tackle critical challenges in bioscience throughcollaborations across academia and industry.Here, the dissolution of boundaries and resultant sharing of knowledge accelerates discovery andinnovation.
The Jennie Smoly Caruthers Biotechnology Building, home of the BioFrontiers Institute: Completed in2012 and expanded in 2017, the 405,000 square foot Jennie Smoly Caruthers BiotechnologyBuilding was designed to facilitate collaborations between scientists andstudents from multipledisciplines as they address critical challenges in the biosciences. Generous donors contributed $62 million toward the $206 million cost of the building.
Lead. Innovate. Impact.
Special thanksto the CU «Ƶ and BioFrontiers Institute team members who contributed to the development of this report: Glenn Asakawa (photographer), Kathy Asta, Cathy Calder (graphic designer),Pat Cavanaugh, Lindsay Diamond, Trent Knoss, Laura Konyha, Dan Larremore, Barbara Monday, Lisa Nanstad, Scott Nordstrom, Kristin Powell, Ashley Rasmussen, Chris Shapard and Shannon Weiman (sciencewriter). August 2018 | HF/CC
Cover Image: Specific disease-inducing mutations can be studied on the molecular and cellular level through a viral expressionsystem. Here, the individual sarcomere bundles of cardiac muscle cells (myocytes) are shown in red.Myocytes expressing the disease-causing protein (shown in green) can be distinguished from those that have not been infected. The nuclei are stained in blue.Esther ChoiILeinwand Lab, BioFrontiers Institute | Nikon A1R Laser Scanning Confocal | BioFrontiers Institute Advanced Light Microscopy Core Facility