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Cells are capable of sensing the differences in elastic and viscous properties (i.e., the ‘viscoelasticity’) of their tissue microenvironment and responding accordingly by changing their transcriptional activity and modifying their behaviors. When

Human mesenchymal stem cells (hMSCs) sense and respond to the bulk elastic and viscoelastic properties of their microenvironment, as well as the spatial distribution of these mechanical signals. Hydrogel substrates with photo-controlled mechanical

Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the heart following myocardial infarction, which is associated with grave morbidity and mortality. To properly mimic native cardiac tissue, materials must not

Numerous diseases, including those of the heart, are characterized by increased stiffness due to excessive deposition of extracellular matrix proteins. Cardiomyocytes continuously adapt their morphology and function to the mechanical changes of

Valvular interstitial cells (VICs) are responsible for the maintenance of the extracellular matrix in heart valve leaflets and, in response to injury, activate from a quiescent fibroblast to a wound healing myofibroblast phenotype. Under normal

The transcatheter aortic valve replacement (TAVR) procedure has emerged as a minimally invasive treatment for patients with aortic valve stenosis (AVS). However, alterations in serum factor composition and biological activity after TAVR remain

CU ��«����Ƶ engineers and faculty from the Consortium for Fibrosis Research & Translation (CFReT) at the CU Anschutz Medical Campus have teamed up to develop biomaterial-based “mimics” of heart tissues to measure patients’ responses to

The American Academy of Arts and Sciences announced today that CU ��«����Ƶ Professor Kristi Anseth has been elected to its 2019 class. Anseth is among more than 200 individuals selected this year for their exceptional achievements in the

Eleven CU ��«����Ƶ researchers were honored in an annual report released by the firm Clarivate Analytics, which recognizes papers that rank in the top one percent of citations for their field and the year in its

The complexities that make each of us unique could result in medications, surgeries or health care devices that treat only the symptoms but not the specific causes. At CU ��«����Ƶ, engineers are inventing novel biomaterials able to decrease pain and