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Protein Kinases (PKs) are allosteric enzymes that play an essential role in signal transduction by regulating a variety of key cellular processes. Most PKs suffer con- formational rearrangements upon phosphorylation that strongly enhance the

Conformational selection by small molecules expands inhibitory possibilities for protein kinases. Nuclear magnetic resonance (NMR) measurements of the mitogen-activated protein (MAP) kinase ERK2 have shown that activation by dual phosphorylation

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis,

The complex inner workings of cells, from their architecture to their signaling, underlie much of multicellular organic life. How are they built? How do their proteins interact? And most crucially, how can understanding these functions improve our

With approval Sept. 14 by the Board of Regents, the University of Colorado has introduced seven newly designated distinguished professors, six of whom are affiliated with the CU ºù«ÍÞÊÓƵ campus. They are Natalie Ahn, James Anaya, Elizabeth Fenn, John

Pioneering biochemistsÌýNatalie Ahn and Karolin Luger have been inducted into theÌýNational Academy of Sciences, an honor that recognizesÌý"distinguished and continuing achievements in original research." Membership in the prestigious

Two CU ºù«ÍÞÊÓƵ professors are among the latest group of scientists, politicians, artists and moreÌýelected to the American Academy of Arts and Science. The academy, which was founded in 1780 and has claimed such luminaries as Albert Einstein and